Beilstein J. Org. Chem.2021,17, 1641–1688, doi:10.3762/bjoc.17.116
, most likely because of enhanced stacking of the bicyclic π-system [104][105]. However, beyond the original studies, 7-Cl-bT has not been further explored for either duplex or triplexstabilization. Similar to L, substitution of thymine with 2-thiouracil (s2U) or 5-halouracils (e.g., BrU, Figure 6
Beilstein J. Org. Chem.2014,10, 1495–1503, doi:10.3762/bjoc.10.154
recognition; triplexstabilization; Introduction
Peptide nucleic acid (PNA) probes are very selective in the recognition of DNA and have been used in a large variety of diagnostic methods, easily allowing the detection of point mutations at very low concentrations [1][2][3]. Poly-pyrimidine PNA can form very
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Graphical Abstract
Figure 1:
(a) TAT triplet structure showing Watson–Crick and Hoogsteen base pairing; the binding can be reinf...